Enantioselective total synthesis of hyperforin.

Citation:

Sparling BA, Moebius DC, Shair MD. Enantioselective total synthesis of hyperforin. J Am Chem Soc. 2013;135 (2) :644-7.

Date Published:

2013 Jan 16

Abstract:

A modular, 18-step total synthesis of hyperforin is described. The natural product was quickly accessed using latent symmetry elements, whereby a group-selective, Lewis acid-catalyzed epoxide-opening cascade cyclization was used to furnish the bicyclo[3.3.1]nonane core and set two key quaternary stereocenters.